Issue 48 of In Defence of Marxism magazine – the quarterly theoretical journal of the Revolutionary Communist International – is out now! Alan Woods’ editorial, which we publish below, takes up the central question of whether we can truly know and understand the world around us, which is a theme throughout this issue. The four articles in this issue take up a wide range of questions relating to this topic: the crisis and stagnation of contemporary science, mysticism in interpreting quantum physics, the philosophical insights of Goethe’s Faust, and a critique of the philosophical writings of Mao.